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Nephrology
Hepatitis C virus infection in chronic kidney disease: paradigm shift in management
So Mi Kim, Il Han Song
Korean J Intern Med. 2018;33(4):670-678. Published online June 28, 2018
Hepatitis C virus (HCV) infection in chronic kidney disease (CKD) is associated with increased liver-related morbidity and mortality rates, accelerated progression to end-stage renal disease, and risk of cardiovascular events. CKD patients with HCV infection require antiviral therapy. Pegylated inte..
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Gastroenterology
Large-scale surveillance study of the safety and effectiveness of entecavir in Korean patients with chronic hepatitis B
Chang Wook Kim, Chang Seop Kim, Hee Yeon Kim, Chang Don Lee, Kyungha Yu, Cyril Llamoso, Heon Ju Lee
Korean J Intern Med. 2018;33(1):91-101. Published online December 13, 2017
Background/Aims: Entecavir (ETV) is effective and safe antiviral agent against hepatitis B virus (HBV) in clinical and real-world setting but, most studies were performed in single institute or have limitation in patient’s number. A large-scale nation-wide real-world surveillance study was carried..
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Development of bronchiolitis obliterans organizing pneumonia during standard treatment of
hepatitis C with Peg-IFNα2b
Eun Chung, Kihoon Park, Jo Heon Kim, Nam Ik Han, Young Sok Lee, Si Hyun Bae, Chung-Hwa Park
Korean J Intern Med. 2017;32(6):1098-1100. Published online August 21, 2017
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Gastroenterology
Clinical implication of serum uric acid level in pegylated interferon and ribavirin combination therapy for chronic hepatitis C infection
In Soo Oh, Joung Won Won, Hyung Joon Kim, Hyun Woong Lee
Korean J Intern Med. 2017;32(6):1010-1017. Published online August 11, 2017
Background/Aims: Combined treatment of pegylated interferon-α (PEG-IFN) and ribavirin (RBV) has long been accepted as the standard treatment for chronic hepatitis C virus (HCV) infection. Many predictive factors for treatment response have been identified. The aim of this study was to evaluate the..
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Long-term real-world entecavir therapy in treatment-naïve hepatitis B patients: base-line
hepatitis B virus DNA and hepatitis B surface antigen levels predict virologic response
Ju-Yeon Cho, Won Sohn, Dong-Hyun Sinn, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Kwang Cheol Koh, Seung Woon Paik, Byung Chul Yoo, Joon Hyeok Lee
Korean J Intern Med. 2017;32(4):636-646. Published online November 4, 2016
Background/Aims: Entecavir is a potent nucleoside analogue with high efficacy and barrier for resistance. We aimed to investigate the long-term efficacy and viral resistance rate of entecavir and explore the factors associated with virologic response, including quantitative hepatitis B surface anti..
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Decreased S100B expression in chronic liver diseases
Su Jung Baik, Tae Hun Kim, Kwon Yoo, Il Hwan Moon, Ju Young Choi, Kyu Won Chung, Dong Eun Song
Korean J Intern Med. 2017;32(2):269-276. Published online June 3, 2016
Background/Aims: Hepatic innervation in liver diseases is not fully understood. We here evaluated S100B expression as a marker of hepatic nerves in patients with various chronic liver diseases, topographically and semi-quantitatively.
Methods: Liver specimens were obtained from 70 subjects (three c..
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Infectious diseases
Incidence and risk factors of hepatitis C virus infection among human immunodeficiency virus
(HIV) patients in a large HIV clinic in South Korea
Shinwon Lee, Sun Hee Lee, Su Jin Lee, Kye-Hyung Kim, Jeong Eun Lee, Heerim Cho, Seung Geun Lee, Joo Seop Chung, Ihm Soo Kwak
Korean J Intern Med. 2016;31(4):772-778. Published online April 27, 2016
Background/Aims: Increasing incidences of hepatitis C virus (HCV) infection in human immunodeficiency virus (HIV)-infected men who have sex were reported in the United States and Europe. However, few studies regarding the epidemiology of HCV infection in HIV-infected patients in Asian countries have..
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Gastroenterology
Incidence of and risk factors for thyroid dysfunction during peginterferon α and ribavirin treatment in patients with chronic hepatitis C
Yong Hwang, Won Kim, So Young Kwon, Hyung Min Yu, Jeong Han Kim, Won Hyeok Choe
Korean J Intern Med. 2015;30(6):792-800. Published online October 30, 2015
Background/Aims: Thyroid dysfunction (TD) is more likely to occur in patients with chronic hepatitis C (CHC) and is particularly associated with interferon (IFN) treatment. The purpose of this study was to investigate the incidence, outcomes, and risk factors for TD during pegylated interferon (PEG-..
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A 2015 roadmap for the management of hepatitis C virus infections in Asia
Seng Gee Lim, Yock Young Dan
Korean J Intern Med. 2015;30(4):423-433. Published online June 29, 2015
The prevalence of hepatitis C virus (HCV) in Asia is 0.5% to 4.7%, with three different genotypes predominating, depending on the geographic region: genotype 1b in East Asia, genotype 3 in South and Southeast Asia, and genotype 6 in Indochina. Official approval for direct-acting antiviral agents (DA..
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Long-term virological outcome in chronic hepatitis B patients with a partial virological response to entecavir
Yu Jung Jo, Kyung-Ah Kim, June Sung Lee, Nam-Hoon Kim, Won Ki Bae, Tae June Song, Jeong Wook Kim
Korean J Intern Med. 2015;30(2):170-176. Published online February 27, 2015
Background/Aims: The clinical outcome of patients with a partial virological response (PVR) to entecavir (ETV), in particular nucloes(t)ide analogue (NA)-experienced patients, has not been thoroughly investigated. The aim of the present study was to assess long-term outcomes in NA-naive and NA-exper..
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Long-term efficacy of tenofovir disoproxil fumarate therapy after multiple nucleos(t)ide analogue failure in chronic hepatitis B patients
Hyo Jin Kim, Ju-Yeon Cho, Yu Jin Kim, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Kwang Cheol Koh, Seung Woon Paik, Byung Chul Yoo, Joon Hyeok Lee
Korean J Intern Med. 2015;30(1):32-41. Published online December 30, 2014
Background/Aims: The efficacy of tenofovir disoproxil fumarate (TDF) for the treatment of chronic hepatitis B (CHB) patients following prior treatment failure with multiple nucleos(t)ide analogues (NAs) is not well defined, especially in Asian populations. In this study we investigated the efficacy ..
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Cryptococcal meningitis in a patient with chronic hepatitis C treated with pegylated-interferon and ribavirin
Tae-Hee Lee, Kee-Ook Lee, Yong-Seok Kim, Sun-Moon Kim, Kyu-Chan Huh, Young-Woo Choi, Young-Woo Kang
Korean J Intern Med. 2014;29(3):370-374. Published online April 29, 2014
Various adverse events have been reported during combination therapy with pegylated (PEG)-interferon-α and ribavirin, although opportunistic infections, especially cryptococcal meningitis, are very rare. A 61-year-old woman complained of headaches and a fever during treatment of a chronic hepatiti..
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Gastroenterology
Survey of perinatal hepatitis B virus transmission after Korean National Prevention Program in a tertiary hospital
Jae Hoon Kim, Ju Seung Kim, Jong Joon Lee, Jung Ho Kim, Suk Young Kim, Young Kul Jung, Oh Sang Kwon, Yun Soo Kim, Duck Joo Choi, Ju Hyun Kim
Korean J Intern Med. 2014;29(3):307-314. Published online April 29, 2014
Background/Aims: The Ministry of Health and Welfare and the Korea Centers for Disease Control and Prevention in South Korea have been organizing hepatitis B virus (HBV) vertical infection prevention projects since July 2002. In this single-institute study, the results of surveys conducted in ..
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Dermatomyositis associated with hepatitis B virus-related hepatocellular carcinoma
Suh Yoon Yang, Bong Ki Cha, Gihyeon Kim, Hyun Woong Lee, Jae Gyu Kim, Sae Kyung Chang, Hyung Joon Kim
Korean J Intern Med. 2014;29(2):231-235. Published online February 27, 2014
Dermatomyositis is an idiopathic inflammatory myopathy with typical cutaneous manifestations. It has been proposed that dermatomyositis may be caused by autoimmune responses to viral infections. Previous studies have shown an association between dermatomyositis and malignant tumors such as ovarian c..
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Gastroenterology
Recent trends in hepatitis B virus infection in the general Korean population
Hyuck Kim, A Ri Shin, Hoe Hoon Chung, Min Kyoung Kim, Ji Sung Lee, Jae-Jun Shim, Byung-Ho Kim
Korean J Intern Med. 2013;28(4):413-419. Published online July 1, 2013
Background/AimsHepatitis B virus (HBV) is the major cause of chronic liver disease in Korea, but viral prevalence has decreased because of hepatitis B vaccination programs. In this study, we investigated longitudinal changes in HBV in fection in the general Korean population.<..
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Experience of Anti-Viral Therapy in Hepatitis B-Associated Membranous Nephropathy, Including Lamivudine-Resistant Strains
In O Sun, Yu Ah Hong, Hoon Suk Park, Sun Ryoung Choi, Byung Ha Chung, Cheol Whee Park, Chul Woo Yang, Yong Soo Kim, Bum Soon Choi
Korean J Intern Med. 2012;27(4):411-416. Published online November 27, 2012
Background/AimsChronic hepatitis B infection is a common cause of secondary membranous nephropathy (MN) in endemic areas. Lamivudine treatment improves renal outcome in patients with hepatitis B virus-associated MN (HBV-MN), but prolonged use leads to the emergence of lamivudi..
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Risk Factors of Cryptogenic Hepatocellular Carcinoma in Patients with Low Body Mass Index or without Metabolic Syndrome
Hwa Young Song, Hyo Keun Lee, June Sung Lee, Jong Yeon Kim, Yun Hyuk Yim, Tae Jun Song, Won Ki Bae, Nam-Hoon Kim, Kyung-Ah Kim
Korean J Intern Med. 2012;27(1):47-52. Published online February 28, 2012
Background/AimsMany patients are diagnosed with cryptogenic hepatocellular carcinoma (HCC) without metabolic syndrome (MS). We investigated the risk factors for cryptogenic HCC in patients with a low body mass index (BMI) or without MS. MethodsT..
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Molecular Epidemiology of Hepatitis B Virus
Jia-Horng Kao
Korean J Intern Med. 2011;26(3):255-261. Published online September 13, 2011
Although safe and effective vaccines for hepatitis B virus (HBV) have been available for nearly three decades, this virus kills at least 600,000 people annually worldwide and remains the leading global cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Because the HBV reverse tr..
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Efficacy of Initial Treatment with Clevudine in Naive Patients with Chronic Hepatitis B
Hyeon Woong Yang, Byung Seok Lee, Tae Hee Lee, Heon Young Lee, Kwan Woo Nam, Young Woo Kang, Hee Bok Chae, Seok Hyun Kim, Seok Bae Kim, Hyang Ie Lee, An Na Kim, Il Han Song, Sae Hwan Lee, Hong Su Kim
Korean J Intern Med. 2010;25(4):372-376. Published online November 27, 2010
Background/AimsClevudine, a pyrimidine nucleoside analogue, has potent antiviral effects in patients with chronic viral hepatitis B (CHB). We report the efficacy of initial treatment with clevudine in naïve patients with CHB living in Daejeon and Chungcheong Province, South ..
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Increased Expression of Cyclooxygenase-2 is Associated with the Progression to Cirrhosis
Soung Won Jeong, Jae Young Jang, Sae Hwan Lee, Sang Gyun Kim, Young Koog Cheon, Young Seok Kim, Young Deok Cho, Hong Soo Kim, Joon Seong Lee, So-Young Jin, Chan Sup Shim, Boo Sung Kim
Korean J Intern Med. 2010;25(4):364-371. Published online November 27, 2010
Background/AimsTo investigate the degree of cyclooxygenase-2 (COX-2) protein expression in chronic hepatitis and cirrhosis. MethodsCOX-2 protein expression was evaluated in 43 cases of chronic hepatitis and 24 cases of cirrhosis using immunohist..
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